When it comes to the subject of favorite handguns for personal defense everybody has their own personal likes, dislikes, and opinions. My selection was based on years and years of trying different makes and models, factoring in reliability, durability, accuracy, mechanical issues if there were any, as well as fit, feel, and function. Of course appearance has to factor in somewhat as well. So what is my favorite personal defense handgun? It would have to be the full size Smith & Wesson M&P 45 in two tone finish.